Neurological Soft Signs and Their Relationship to Cognitive and Clinical Efficacy of Atypical Antipsychotics in Schizophrenia
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چکیده
منابع مشابه
Neurological soft signs and their relationship to cognitive and clinical efficacy of atypical antipsychotics in schizophrenia.
Neurological soft signs (NSS) are nonspecific indicators of brain dysfunction that are found to be in excess and correlated with cognitive dysfunction and psychopathology in patients with schizophrenia. The aim of the study was to examine whether the severity of NSS determines the efficacy of atypical antipsychotics in schizophrenia. Forty-three patients with schizophrenia were assessed on psyc...
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This prospective study examined the course of neurological soft signs (NSS) in patients with first-episode schizophrenia and its relationship with negative symptoms and cognitive functions. One hundred and forty-five patients with first-episode schizophrenia were recruited, 29 were classified as having prominent negative symptoms. NSS and neuropsychological measures were administered to all pat...
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Among 16 chronic schizophrenic in-patients, all had at least one neurological soft sign (NSS), and 6 (40%) had definite neurodysfunction. NSS and TD scores were highly intercorrelated, and NSS were significantly correlated with neuroleptic drug exposure. NSS correlated positively with both positive and negative symptoms and cognitive impairment but not with cerebral ventricular size on CT. Pati...
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15 صفحه اولNeurological Soft Signs in First -Episode Schizophrenia
Neurological soft signs (NSS) refer to subtle neurological abnormalities comprising deficits in sensory integration, motor coordination, or sequencing of complex motor acts. It is generally accepted that NSS are more prevalent in schizophrenia patients, including first -episode cases, than in healthy subjects. Moreover, NSS have been consistently demonstrated in neuroleptic naïve firstepisode p...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2004
ISSN: 0586-7614,1745-1701
DOI: 10.1093/oxfordjournals.schbul.a007075